Acomplia produced disappointing results in slowing progression of coronary artery disease in patients and it significantly raised the risk of anxiety and depression, according to a report in the April 2 issue of the Journal of the American Medical Association.
More than 20 percent of patients who took rimonabant in the STRADIVARIUS trial developed psychiatric problems, the researchers reported.
While Acomplia is sold in European Union countries and some other nations, Sanofi Aventis pulled back its U.S. application last year after an FDA advisory panel recommended against approval of rimonabant because of concerns over psychiatric risks.
The researchers reported that the study failed to meet its main goal of reducing the Percent Atheroma Volume (PAV), a measure of plaque in a cross-section of the arteries, although it did reduce the Total Atheroma Volume (TAV), a measurement of total plaque in the coronary artery.
But more attention seems certain to be focused on this latest effort to assess the extent to which Acomplia carries with it an increased risk of psychiatric side effects.
The researchers in the STRADIVARIUS study included patients with a history of such problems, and reported that 23.4 percent of patients who got Acomplia suffered psychiatric side effects such as depression and anxiety compared to 18.4 percent of patients who were in the control group.
But despite that ,reserchers have also goosd news about Acomplia.They descovered why this amaizing diet pill has some side effects.
Acomplia, in addition to promoting weight loss by blocking the body’s CB-1 receptors, may also block a receptor in the brain called TRPV1, possibly explaining why the diet pill produces depression, anxiety and suicidal thoughts in some patients, according to researchers.
“It’s possible that when people are taking the drug rimonabant, and the dose range is correct, it may not affect TRPV1 at all,” A specialist said. “However, in some people, Acomplia could be hitting TRPV1 and may well have an effect on activating this receptor,so the solution could be here”
So with the right dosage Acomplia may not affect people at all,but now this great discovery people could use a higher dosage without any side effect.
This is a great news for all over weight people ,that need help to change their lifes,so all we can hope now is that reserchers use properlly this discovery and the FDA finally to aprove this amaizing pill,Acomplia .